Mesangial C4d deposition: a new prognostic factor in IgA nephropathy
Extract:
It has been shown that patients with IgA nephropathy can be divided
into two groups on the basis of the pattern of complement activation.
Activation of the lectin pathway of complement is associated with more
severe renal disease. Glomerular deposition of C4d is a marker of
activation of the lectin pathway of complement. The aim of our study
was to determine whether C4d staining at the time of the renal biopsy
could identify patients with a different long-term prognosis in IgA
nephropathy.
You can read the rest of the abstract at:
http://ndt.oxfordjournals.org/cgi/content/abstract/24/3/886
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